Real World Studies: What They Are and What They Are Not

Patients are filtered by rigorously defined study selection criteria for recruitment into research; this is necessary to improve signal detection, internal validity, reduce study-related risks, and meet ethical standards. Research patients assessed managed in ways that differ from usual practice. So, neither nor the treatment environment resembles everyday treated This diminishes generalizability of findings; is, their external validity. There therefore, an increasing trend conduct “real-world studies.” In context, patients” those who not restrictive criteria, settings” which with few guidelines restrictions. The elephant room glamour associated such real-world studies illusion. because one setting can widely another setting. even studies, we only generalize findings population sample was drawn managed. As a final note, many assessments research, as computerized or pen-and-paper neuropsychological tests, measures are, example, activities daily living quality life.